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Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.

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第一作者： Yasmin,Bay

第一单位： Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

作者： Yasmin,Bay ^[1] ; Raminta,Venskutonytė ^[1] ; Stine M,Frantsen ^[1] ; Thor S,Thorsen ^[1] ; Maria,Musgaard ^[2] ; Karla,Frydenvang ^[1] ; Pierre,Francotte ^[3] ; Bernard,Pirotte ^[3] ; Philip C,Biggin ^[2] ; Anders S,Kristensen ^[1] ; Thomas,Boesen ^[4] ; Darryl S,Pickering ^[1] ; Michael,Gajhede ^[1] ; Jette S,Kastrup ^[1]

作者单位： Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. ^[1] Department of Biochemistry, University of Oxford, UK. ^[2] Department of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, Belgium. ^[3] Danish Research Institute of Translational Neuroscience-DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Department of Molecular Biology and Genetics, Aarhus University, Denmark. ^[4]

关键词 X‐ray crystallography calcium‐sensitive fluorescence‐based assays electron microscopy kainate receptors molecular dynamics simulations

医学主题词受体, 红藻氨酸(Receptors, Kainic Acid);红藻氨酸(Kainic Acid);环硫氧化物(Cyclic S-Oxides);锌(Zinc);噻嗪类(Thiazines)

DOI 10.1111/febs.17046

PMID 38145505

发布时间 2024-04-04

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准确一般字义偏差语意偏离译文作用小提交