首页> Thorax> Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).

Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).

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第一作者： Puja,Mehta

第一单位： Centre for inflammation and Tissue Repair (CITR), University College London Division of Medicine, London, UK.

作者： Puja,Mehta ^[1] ; Romit J,Samanta ^[2] ; Katherine,Wick ^[3] ; Rebecca C,Coll ^[4] ; Thea,Mawhinney ^[4] ; Patrick G,McAleavey ^[4] ; Andrew J,Boyle ^[5] ; John,Conlon ^[4] ; Manu,Shankar-Hari ^[6] ; Angela,Rogers ^[7] ; Carolyn S,Calfee ^[8] ; Michael A,Matthay ^[8] ; Charlotte,Summers ^[2] ; Rachel Clare,Chambers ^[9] ; Daniel Francis,McAuley ^[5] ; Cecilia M,O'Kane ^[10]

作者单位： Centre for inflammation and Tissue Repair (CITR), University College London Division of Medicine, London, UK. ^[1] Department of Medicine, University of Cambridge, Cambridge, UK. ^[2] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA. ^[3] Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK. ^[4] Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.;Royal Victoria Hospital, Belfast Health and Social Care Trust, Belfast, UK. ^[5] The Queen's Medical Research Institute, Edinburgh BioQuarter, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.;Intensive Care Medicine, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK. ^[6] Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, California, USA. ^[7] Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA.;Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, California, USA. ^[8] Centre for Inflammation and Tissue Repair, UCL, London, UK. ^[9] Wellcome Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK c.okane@qub.ac.uk. ^[10]

关键词 ARDS Critical Care Cytokine Biology

医学主题词人类(Humans);前瞻性研究(Prospective Studies);白细胞介素18(Interleukin-18);斯伐他汀(Simvastatin);炎症(Inflammation)

DOI 10.1136/thorax-2023-220292

PMID 38148147

发布时间 2025-07-23

基金项目