Insulin granule morphology and crinosome formation in mice lacking the pancreatic β cell-specific phogrin (PTPRN2) gene.

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作者： Tadashi,Yasui ^[1] ; Mutsumi,Mashiko ^[1] ; Akihiro,Obi ^[1] ; Hiroyuki,Mori ^[1] ; Moeko,Ito-Murata ^[1] ; Hiroki,Hayakawa ^[1] ; Shota,Kikuchi ^[1] ; Masahiro,Hosaka ^[2] ; Chisato,Kubota ^[3] ; Seiji,Torii ^[4] ; Hiroshi,Gomi ^[3]

作者单位： Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan. ^[1] Laboratory of Molecular Life Sciences, Department of Biotechnology, Akita Prefectural University, 241-438 Kaidobata-nishi, Nakano Shimoshinjo, Akita, 010-0195, Japan. ^[2] Center for Food Science and Wellness, Gunma University, 3-39-22 Showa, Maebashi, Gunma, 371-8511, Japan. ^[3] Takasaki University of Health and Welfare, 37-1 Nakaorui, Takasaki, Gunma, 370-0033, Japan. ^[4] Department of Veterinary Anatomy, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan. gomi.hiroshi@nihon-u.ac.jp. ^[5]

关键词 Crinophagy Crinosome IA-2β Insulin granule Lysosome Phogrin

主题词动物(Animals);小鼠(Mice);葡萄糖(Glucose);胰岛素(Insulin);胰岛素分泌细胞(Insulin-Secreting Cells);膜蛋白质类(Membrane Proteins);小鼠, 基因敲除(Mice, Knockout)

DOI 10.1007/s00418-023-02256-8

PMID 38150052

发布时间 2024-03-06

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