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Potassium ion efflux induces exaggerated mitochondrial damage and non-pyroptotic necrosis when energy metabolism is blocked.

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第一作者： Rong,Xu

第一单位： State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

作者： Rong,Xu ^[1] ; Li-Sha,Yuan ^[2] ; Ying-Qing,Gan ^[2] ; Na,Lu ^[2] ; Ya-Ping,Li ^[3] ; Zhi-Ya,Zhou ^[2] ; Qing-Bing,Zha ^[4] ; Xian-Hui,He ^[5] ; Tak-Sui,Wong ^[6] ; Dong-Yun,Ouyang ^[7]

作者单位： State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. ^[1] Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. ^[2] Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, The Fifth Affiliated Hospital of Jinan University, Heyuan 517000, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China. ^[3] Department of Clinical Laboratory, The Fifth Affiliated Hospital of Jinan University, Heyuan 517000, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China; Department of Fetal Medicine, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China. ^[4] Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Clinical Laboratory, The Fifth Affiliated Hospital of Jinan University, Heyuan 517000, China; Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, The Fifth Affiliated Hospital (Heyuan Shenhe People's Hospital), Jinan University, Heyuan 517000, China. Electronic address: thexh@jnu.edu.cn. ^[5] Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China. Electronic address: huangdx@jnu.edu.cn. ^[6] State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China; Department of Immunobiology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Electronic address: dongyun1967@aliyun.com. ^[7]

关键词 Fructose-1,6-bisphosphate Glucose metabolism Mitochondrial damage NLRP3 inflammasome activation Potassium efflux Reactive oxygen species