Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults.

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第一作者： Mathilde Suhr,Hemminghyth

第一单位： Department of Research and Innovation, Research Group for Age-Related Medicine, Helse Fonna, Haugesund Hospital, Haugesund, Norway; Department of Neuropsychology, Helse Fonna, Haugesund Hospital, Haugesund, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway. Electronic address: mathildesh@hotmail.com.

作者： Mathilde Suhr,Hemminghyth ^[1] ; Luiza Jadwiga,Chwiszczuk ^[2] ; Monica Haraldseid,Breitve ^[3] ; Berglind,Gísladóttir ^[4] ; Gøril Rolfseng,Grøntvedt ^[5] ; Arne,Nakling ^[6] ; Arvid,Rongve ^[7] ; Tormod,Fladby ^[8] ; Bjørn-Eivind,Kirsebom ^[9]

作者单位： Department of Research and Innovation, Research Group for Age-Related Medicine, Helse Fonna, Haugesund Hospital, Haugesund, Norway; Department of Neuropsychology, Helse Fonna, Haugesund Hospital, Haugesund, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway. Electronic address: mathildesh@hotmail.com. ^[1] Department of Research and Innovation, Research Group for Age-Related Medicine, Helse Fonna, Haugesund Hospital, Haugesund, Norway; Department of Age-related Medicine, Helse Fonna, Haugesund Hospital, Haugesund, Norway. ^[2] Department of Research and Innovation, Research Group for Age-Related Medicine, Helse Fonna, Haugesund Hospital, Haugesund, Norway; Department of Neuropsychology, Helse Fonna, Haugesund Hospital, Haugesund, Norway; Department of Age-related Medicine, Helse Fonna, Haugesund Hospital, Haugesund, Norway. ^[3] Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Clinical Molecular Biology (EpiGen), Medical Division, Akershus University Hospital and University of Oslo, Norway. ^[4] Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway. ^[5] Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway. ^[6] Department of Research and Innovation, Research Group for Age-Related Medicine, Helse Fonna, Haugesund Hospital, Haugesund, Norway; Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway; Department of Age-related Medicine, Helse Fonna, Haugesund Hospital, Haugesund, Norway. ^[7] Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. ^[8] Department of Neurology, University Hospital of North Norway, Tromsø, Norway; Department of Psychology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway. ^[9]

关键词 Cognition Learning and memory Neurofilament light chain Normal aging Total-tau

主题词人类(Humans);中间丝(Intermediate Filaments);淀粉样β肽类(Amyloid beta-Peptides);tau蛋白质类(tau Proteins);神经微丝蛋白质类(Neurofilament Proteins);衰老(Aging);阿尔茨海默病(Alzheimer Disease)

DOI 10.1016/j.neurobiolaging.2023.12.005

PMID 38159464

发布时间 2024-12-26

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