Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery.

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第一作者： Savan K,Patel

第一单位： Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

作者： Savan K,Patel ^[1] ; Margaret M,Billingsley ^[1] ; Alvin J,Mukalel ^[1] ; Ajay S,Thatte ^[1] ; Alex G,Hamilton ^[1] ; Ningqiang,Gong ^[1] ; Rakan,El-Mayta ^[2] ; Hannah C,Safford ^[1] ; Maria,Merolle ^[2] ; Michael J,Mitchell ^[3]

作者单位： Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[1] Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[2] Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.;Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.;Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[3]

关键词 extrahepatic delivery lipid nanoparticles mRNA

主题词胆汁酸类和盐类(Bile Acids and Salts);RNA, 信使(RNA, Messenger);纳米粒子(Nanoparticles);脂类(Lipids);胆固醇(Cholesterol);胆酸类(Cholic Acids);RNA, 小分子干扰(RNA, Small Interfering)

DOI 10.7150/thno.89913

PMID 38164140

发布时间 2024-10-19

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