Development and characterization of a novel neutralizing scFv vectored immunoprophylaxis against botulinum toxin type A.

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作者： Yongpeng,Wei ^[1] ; Guangyao,Li ^[2] ; Zhuo,Wang ^[1] ; Kewen,Qian ^[3] ; Shuyi,Zhang ^[1] ; Lingling,Zhang ^[2] ; Changhai,Lei ^[1] ; Shi,Hu ^[3]

作者单位： Department of Biophysics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, China. ^[1] Hepatic Surgery Department V, The Third Affiliated Hospital, Second Military Medical University, Shanghai, China. ^[2] Department of Biomedical Engineering, College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai, China. ^[3] Department of Central Laboratory, Clinical Research Center of Changhai Hospital, Shanghai, China. ^[4]

关键词 Botulinum toxin type A adeno-associated virus hybridoma technology monoclonal antibody single chain fragment variable vectored immunoprophylaxis

主题词人类(Humans);肉毒杆菌毒素类, A型(Botulinum Toxins, Type A);肉毒中毒(Botulism);肉毒梭状杆菌(Clostridium botulinum);抗体, 单克隆(Antibodies, Monoclonal);抗病毒药(Antiviral Agents)

DOI 10.1080/1061186X.2023.2301418

PMID 38164940

发布时间 2024-06-12

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