Knockdown of the Non-canonical Wnt Gene Prickle2 Leads to Cerebellar Purkinje Cell Abnormalities While Cerebellar-Mediated Behaviors Remain Intact.

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作者： Parker W,Abbott ^[1] ; Jason B,Hardie ^[1] ; Kyle P,Walsh ^[1] ; Aaron J,Nessler ^[2] ; Sean J,Farley ^[3] ; John H,Freeman ^[1] ; John A,Wemmie ^[1] ; Linder,Wendt ^[4] ; Young-Cho,Kim ^[5] ; Levi P,Sowers ^[6] ; Krystal L,Parker ^[7]

作者单位： Department of Psychiatry, Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA.;Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52245, USA. ^[1] Department of Biochemistry, The University of Iowa, Iowa City, IA, 52245, USA. ^[2] The University of Iowa, Iowa City, IA, 52242, USA. ^[3] Department of Biostatistics, The University of Iowa, Iowa City, IA, 52245, USA. ^[4] Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52245, USA.;Department of Neurology, The University of Iowa, Iowa City, IA, 52245, USA. ^[5] Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52245, USA.;Department of Pediatrics, The University of Iowa, Iowa City, IA, 52245, USA. ^[6] Department of Psychiatry, Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52242, USA. krystal-parker@uiowa.edu.;Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, 52245, USA. krystal-parker@uiowa.edu. ^[7]

关键词 Autism spectrum disorders Cerebellum Cognition Purkinje cells Wnt signaling