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Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy.

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作者单位: Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. [1] Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, Perth, Western Australia, Australia. [2] Curtin Medical School, Curtin University, Perth, Western Australia, Australia. [3] Storr Liver Centre, The Westmead Institute for Medical Research and Westmead Hospital, University of Sydney, Sydney, New South Wales, Australia. [4] Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. [5] Shanghai Institute of Transplantation, Shanghai, China. [6] Department of Biliary Tract Surgery I, Eastern Hepatobiliary Surgery Hospital, Shanghai, China. [7] BGI-Shenzhen, Beishan Industrial Zone, Shenzhen, P. R. China. [8] BGI-Australia, Herston, Queensland, Australia. [9] Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore. [10] Telethon Kids Institute, University of Western Australia, Perth Children's Hospital, Nedlands, Western Australia, Australia. [11] Department of Hepatology and Western Australian Liver Transplant Service, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. [12] Medical School, University of Western Australia, Nedlands, Western Australia, Australia. [13] Department of Obstetrics and Gynecology, Xinhua Hospital Affiliated to Shanghai Jiaotong University Medicine School, Shanghai, China. [14] Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. [15] Academic Clinical Program in Obstetrics and Gynaecology, Duke-NUS Medical School, Singapore, Singapore. [16] Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. [17] Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore. pierce.chow@duke-nus.edu.sg. [18] Surgery Academic Clinical Programme, Duke-NUS Medical School, Singapore, Singapore. pierce.chow@duke-nus.edu.sg. [19] Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. florent_ginhoux@immunol.a-star.edu.sg. [20] Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore. florent_ginhoux@immunol.a-star.edu.sg. [21] Translational Immunology Institute, SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore. florent_ginhoux@immunol.a-star.edu.sg. [22] Gustave Roussy Cancer Campus, Villejuif, France. florent_ginhoux@immunol.a-star.edu.sg. [23] Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, Perth, Western Australia, Australia. ankur.sharma@perkins.org.au. [24] Curtin Medical School, Curtin University, Perth, Western Australia, Australia. ankur.sharma@perkins.org.au. [25] Institute of Molecular and Cell Biology, A∗STAR, Singapore, Singapore. ankur.sharma@perkins.org.au. [26] KK Research Centre, KK Women's and Children's Hospital, Singapore, Singapore. ankur.sharma@perkins.org.au. [27]
DOI 10.1038/s43018-023-00672-2
PMID 38168935
发布时间 2024-02-06
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Nature cancer

Nature cancer

2024年5卷1期

167-186页

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