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GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway.

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作者: Ann Y,Park [1] ; Michael,Leney-Greene [2] ; Matthew,Lynberg [1] ; Justin Q,Gabrielski [1] ; Xijin,Xu [1] ; Benjamin,Schwarz [3] ; Lixin,Zheng [1] ; Arasu,Balasubramaniyam [4] ; Hyoungjun,Ham [5] ; Brittany,Chao [1] ; Yu,Zhang [5] ; Helen F,Matthews [1] ; Jing,Cui [1] ; Yikun,Yao [1] ; Satoshi,Kubo [1] ; Jean Michel,Chanchu [1] ; Aaron R,Morawski [1] ; Sarah A,Cook [1] ; Ping,Jiang [1] ; Juan C,Ravell [6] ; Yan H,Cheng [1] ; Alex,George [1] ; Aiman,Faruqi [1] ; Alison M,Pagalilauan [1] ; Jenna R E,Bergerson [7] ; Sundar,Ganesan [8] ; Samuel D,Chauvin [1] ; Jahnavi,Aluri [1] ; Joy,Edwards-Hicks [9] ; Eric,Bohrnsen [3] ; Caroline,Tippett [10] ; Habib,Omar [1] ; Leilei,Xu [1] ; Geoffrey W,Butcher [11] ; John,Pascall [11] ; Elif,Karakoc-Aydiner [12] ; Ayca,Kiykim [13] ; Holden,Maecker [14] ; İlhan,Tezcan [15] ; Saliha,Esenboga [15] ; Raul Jimenez,Heredia [16] ; Deniz,Akata [17] ; Saban,Tekin [18] ; Altan,Kara [19] ; Zarife,Kuloglu [20] ; Emel,Unal [21] ; Tanıl,Kendirli [22] ; Figen,Dogu [23] ; Esra,Karabiber [24] ; T Prescott,Atkinson [25] ; Claude,Cochet [26] ; Odile,Filhol [26] ; Catherine M,Bosio [3] ; Mark M,Davis [27] ; Richard P,Lifton [28] ; Erika L,Pearce [29] ; Oliver,Daumke [30] ; Caner,Aytekin [31] ; Gülseren Evirgen,Şahin [32] ; Aysel Ünlüsoy,Aksu [32] ; Gulbu,Uzel [7] ; V,Koneti Rao [7] ; Sinan,Sari [33] ; Buket,Dalgıç [33] ; Kaan,Boztug [34] ; Deniz,Cagdas [15] ; Sule,Haskologlu [23] ; Aydan,Ikinciogullari [23] ; David,Schwefel [35] ; Silvia,Vilarinho [10] ; Safa,Baris [12] ; Ahmet,Ozen [12] ; Helen C,Su [5] ; Michael J,Lenardo [36]
作者单位: Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. [1] Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. [2] Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA. [3] Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Department of Structural Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany. [4] Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. [5] Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.;Department of Internal Medicine, Hackensack Meridian School of Medicine, Nutley, NJ, USA. [6] Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. [7] Biological Imaging Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. [8] Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany. [9] Section of Digestive Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.;Department of Pathology, Yale School of Medicine, New Haven, CT, USA. [10] Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Cambridge, United Kingdom. [11] Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine Pendik, Istanbul, Turkey.;The Isil Berat Barlan Center for Translational Medicine, Marmara University, Pendik, Istanbul, Turkey. [12] Division of Pediatric Allergy and Immunology, Marmara University, School of Medicine Pendik, Istanbul, Turkey. [13] Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Palo Alto, CA, USA. [14] Department of Pediatrics, Division of Pediatric Immunology, Hacettepe University, Faculty of Medicine, Ankara, Turkey. [15] St Anna Children's Cancer Research Institute, Vienna, Austria.;Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.;Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. [16] Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. [17] Department of Basic Medical Sciences, Hamidiye Faculty of Medicine, Division of Medical Biology, University of Health Sciences, İstanbul, Turkey. [18] TUBITAK Marmara Research Center, Gene Engineering and Biotechnology Institute, Gebze, Turkey. [19] Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Ankara University School of Medicine, Ankara, Türkiye. [20] Department of Pediatric Oncology, Ankara University Medical School, Ankara, Turkey. [21] Department of Pediatric Intensive Care Unit, Ankara University Medical School, Ankara, Turkey. [22] Department of Pediatric Immunology and Allergy, Ankara University Medical School, Ankara, Turkey. [23] Department of Chest Diseases, Faculty of Medicine, Division of Adult Allergy-Immunology, Marmara University, Istanbul, Turkey. [24] Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA. [25] University Grenoble Alpes, INSERM, CEA, UMR Biosanté, Grenoble, France. [26] Institute for Immunity, Transplantation and Infection, Stanford University, Palo Alto, CA, USA. [27] Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.;Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA. [28] Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.;The Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Johns Hopkins University, Baltimore, MD, USA. [29] Department of Structural Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.;Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany. [30] Department of Pediatric Immunology, Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey. [31] Department of Pediatric Gastroenterology, Hepatology and Nutrition, University of Health Sciences, Dr Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey. [32] Department of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey. [33] St Anna Children's Cancer Research Institute, Vienna, Austria.;Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.;Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.;CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.;St Anna Children's Hospital, Vienna, Austria. [34] Department of Structural Biology, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.;Institute for Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany.;Bioanalytics Unit, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany. [35] Molecular Development of the Immune System Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. lenardo@nih.gov.;Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. lenardo@nih.gov. [36]
DOI 10.1038/s41590-023-01691-y
PMID 38172257
发布时间 2025-02-02
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