Selection and identification of a prohibitin 2-binding DNA aptamer for tumor tissue imaging and targeted chemotherapy.

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作者： Yan,Qiao ^[1] ; Yanli,Shi ^[2] ; Mengmeng,Ji ^[3] ; Zhaoting,Wang ^[3] ; Xue,Bai ^[3] ; Kai,Zhang ^[3] ; Kai,Yin ^[3] ; Yangyang,Zhang ^[3] ; Xinhuan,Chen ^[1] ; Yueteng,Zhang ^[4] ; Jing,Lu ^[1] ; Jimin,Zhao ^[1] ; Kangdong,Liu ^[5] ; Baoyin,Yuan ^[6]

作者单位： Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China; Henan Provincial Cooperative Innovation Center for Cancer Chemoprevention, Zhengzhou 450000, Henan, China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou 450001, Henan, China. ^[1] Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China; Department of Pathology, Zhoukou Central Hospital, Zhoukou 466000, Henan, China. ^[2] Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China. ^[3] Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou 450001, Henan, China. ^[4] Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China; Henan Provincial Cooperative Innovation Center for Cancer Chemoprevention, Zhengzhou 450000, Henan, China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou 450001, Henan, China; China-US (Henan) Hormel Cancer Institute, Zhengzhou 450003, Henan, China; Cancer Chemoprevention International Collaboration Laboratory, Zhengzhou 450000, Henan, China. Electronic address: kdliu@zzu.edu.cn. ^[5] Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China; Henan Provincial Cooperative Innovation Center for Cancer Chemoprevention, Zhengzhou 450000, Henan, China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou 450001, Henan, China. Electronic address: yuanbaoyin@zzu.edu.cn. ^[6]

关键词 DNA aptamer Prohibitin 2 Tumor diagnosis and therapy

主题词人类(Humans);适体, 核苷(Aptamers, Nucleotide);多柔比星(Doxorubicin);肿瘤(Neoplasms);SELEX适体技术(SELEX Aptamer Technique);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1016/j.ijbiomac.2023.129002

PMID 38176501

发布时间 2024-02-22

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