Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma.

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作者： Sharmeen,Ishteyaque ^[1] ; Gurvinder,Singh ^[2] ; Karan Singh,Yadav ^[1] ; Smriti,Verma ^[1] ; Rakesh Kumar,Sharma ^[3] ; Sumati,Sen ^[4] ; Anurag Kumar,Srivastava ^[5] ; Kalyan,Mitra ^[3] ; Amit,Lahiri ^[6] ; Dnyaneshwar U,Bawankule ^[4] ; Srikanta Kumar,Rath ^[5] ; Dinesh,Kumar ^[7] ; Madhav Nilakanth,Mugale ^[8]

作者单位： Division of Cancer Biology CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226031, India; Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[1] Department of Advanced Spectroscopy and Imaging, Centre of Biomedical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow-226014, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[2] Sophisticated Analytical Instrument Facility and Research Division CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[3] Bioprospection and Product Development Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh 226015, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[4] Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226031, India. ^[5] Pharmacology Division, CSIR - Central Drug Research Institute (CSIR-CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. ^[6] Department of Advanced Spectroscopy and Imaging, Centre of Biomedical Research (CBMR), SGPGIMS Campus, Raebareli Road, Lucknow-226014, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: dinesh@cbmr.res.in. ^[7] Division of Cancer Biology CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226031, India; Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute (CSIR-CDRI), Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: madhav.mugale@cdri.res.in. ^[8]

关键词 Drp-1 Ketolysis Mitochondrial dysfunction NF-κβ NMR based serum and tissue metabolomics STAT3 Succinate