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Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells.

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第一作者： Seyed M,Ghiasi

第一单位： Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London Du Cane Road, London W12 0NN, United Kingdom.;Department of Biomedical Sciences, University of Copenhagen, 3 Blegdamsvej, 2200 Copenhagen N, Denmark.;Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.

作者： Seyed M,Ghiasi ^[1] ; Piero,Marchetti ^[2] ; Lorenzo,Piemonti ^[3] ; Jens H,Nielsen ^[4] ; Bo T,Porse ^[5] ; Thomas,Mandrup-Poulsen ^[4] ; Guy A,Rutter ^[6]

作者单位： Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London Du Cane Road, London W12 0NN, United Kingdom.;Department of Biomedical Sciences, University of Copenhagen, 3 Blegdamsvej, 2200 Copenhagen N, Denmark.;Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. ^[1] Department of Clinical and Experimental Medicine, Islet Cell Laboratory, University of Pisa, 56126, Pisa, Italy. ^[2] Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milano, Italy. ^[3] Department of Biomedical Sciences, University of Copenhagen, 3 Blegdamsvej, 2200 Copenhagen N, Denmark. ^[4] Biotech Research and Innovation Centre (BRIC), University of Copenhagen, 3 Blegdamsvej, 2200 Copenhagen N, Denmark.;The Finsen Laboratory, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.;Danish Stem Cell Center (DanStem) Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. ^[5] Section of Cell Biology and Functional Genomics, Division of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London Du Cane Road, London W12 0NN, United Kingdom.;CHUM Research Centre (CRCHUM) and Faculty of Medicine, University of Montreal, 900 Rue St. Denis, Montreal, QC, Canada.;Lee Kong Chian School of Medicine, Nanyang Technological University, 637553, Singapore. ^[6]

关键词 RNA decay RNA processing insulin secretion nonsense-mediated decay transcript β-cells

DOI 10.1101/2023.12.20.572623

PMID 38187722

发布时间 2024-04-22

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Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells.

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Proinflammatory Cytokines Suppress Nonsense-Mediated RNA Decay to Impair Regulated Transcript Isoform Processing in Pancreatic β-Cells.

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