Improving stroke outcomes in hyperglycemic mice by modulating tPA/NMDAR signaling to reduce inflammation and hemorrhages.

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第一作者： Florent,Lebrun

第一单位： Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, Institute Blood and Brain @ Caen-Normandie, Caen, France.;STROK@LLIANCE, ETAP-Lab, Caen, France.

作者： Florent,Lebrun ^[1] ; Damien,Levard ^[2] ; Eloïse,Lemarchand ^[2] ; Mervé,Yetim ^[2] ; Jonathane,Furon ^[2] ; Fanny,Potzeha ^[2] ; Pauline,Marie ^[2] ; Flavie,Lesept ^[3] ; Manuel,Blanc ^[3] ; Benoit,Haelewyn ^[4] ; Marina,Rubio ^[2] ; Annelise,Letourneur ^[5] ; Nicolas,Violle ^[5] ; Cyrille,Orset ^[6] ; Denis,Vivien ^[7]

作者单位： Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, Institute Blood and Brain @ Caen-Normandie, Caen, France.;STROK@LLIANCE, ETAP-Lab, Caen, France. ^[1] Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, Institute Blood and Brain @ Caen-Normandie, Caen, France. ^[2] Lys Therapeutics, HQ: Cyceron, Caen, France. ^[3] GIP Cyceron, Caen, France.;Experimental Stroke Research Platform, Normandie University, CURB, Caen, France. ^[4] STROK@LLIANCE, ETAP-Lab, Caen, France. ^[5] Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, Institute Blood and Brain @ Caen-Normandie, Caen, France.;Experimental Stroke Research Platform, Normandie University, CURB, Caen, France. ^[6] Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders, GIP Cyceron, Institute Blood and Brain @ Caen-Normandie, Caen, France.;Experimental Stroke Research Platform, Normandie University, CURB, Caen, France.;Department of Clinical Research, Caen-Normandie University Hospital, Caen, France. ^[7]

主题词小鼠(Mice);动物(Animals);人类(Humans);组织型纤溶酶原激活物(Tissue Plasminogen Activator);小鼠, 肥胖(Mice, Obese);卒中(Stroke);出血(Hemorrhage);炎症(Inflammation);高血糖症(Hyperglycemia)

DOI 10.1182/bloodadvances.2023011744

PMID 38190586

发布时间 2024-11-05

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Blood advances

2024年8卷5期

1330-1344页

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Improving stroke outcomes in hyperglycemic mice by modulating tPA/NMDAR signaling to reduce inflammation and hemorrhages.

Blood advances

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Improving stroke outcomes in hyperglycemic mice by modulating tPA/NMDAR signaling to reduce inflammation and hemorrhages.

Blood advances

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Blood advances

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