IFN-λ3 is induced by <i>Leishmania donovani</i> and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.

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第一作者： Manjarika,De

第一单位： National Institute of Biomedical Genomics, Kalyani, West Bengal, India.

作者： Manjarika,De ^[1] ; Soumi,Sukla ^[2] ; Seema,Bharatiya ^[3] ; Sagar,Keshri ^[1] ; Debarati Guha,Roy ^[4] ; Sutopa,Roy ^[1] ; Debrupa,Dutta ^[4] ; Shriya,Saha ^[1] ; Sarfaraz Ahmad,Ejazi ^[4] ; V,Ravichandiran ^[5] ; Nahid,Ali ^[2] ; Mitali,Chatterjee ^[1] ; Sreedhar,Chinnaswamy ^[6]

作者单位： National Institute of Biomedical Genomics, Kalyani, West Bengal, India. ^[1] National Institute of Pharmaceutical Education and Research, Kolkata, West Bengal, India. ^[2] Centre for High Impact Neuroscience and Translational Applications (CHINTA), TCG-Centres for Research and Education in Science and Technology, Kolkata, West Bengal, India. ^[3] Regional Centre for Biotechnology, Faridabad, India. ^[4] Department of Pharmacology, Institute of Post-Graduate Medical Education and Research, Kolkata, India. ^[5] Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India. ^[6] Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, MD, USA. ^[7]

关键词 IFN-L3 Leishmania Leishmania donovani post-kala-azar dermal leishmaniasis type III IFN visceral leishmaniasis