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Synthesis and characterization of bis-amide SSE1917 as a microtubule-stabilizing anticancer agent.

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第一作者： Sana,Iqbal

第一单位： Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Pakistan.

作者： Sana,Iqbal ^[1] ; Farhat,Firdous ^[2] ; Muhammad,Furqan ^[3] ; Aishah,Bilal ^[3] ; Salman,Fozail ^[3] ; Sebastian Öther-Gee,Pohl ^[4] ; Nora Julia,Doleschall ^[4] ; Kevin B,Myant ^[4] ; Upendra,Singh ^[5] ; Abdul-Hamid,Emwas ^[6] ; Mariusz,Jaremko ^[5] ; Amir,Faisal ^[7] ; Rahman Shah Zaib,Saleem ^[8]

作者单位： Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Pakistan. ^[1] Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Pakistan; Department of Life Sciences, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Pakistan. ^[2] Department of Life Sciences, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Pakistan. ^[3] Institute of Genetics and Cancer, The University of Edinburgh, Western General Hospital Campus, Crewe Road, Edinburgh EH4 2XU, Scotland, United Kingdom. ^[4] Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. ^[5] KAUST Core Labs, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia. ^[6] Department of Life Sciences, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Pakistan. Electronic address: amir.faisal@lums.edu.pk. ^[7] Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences, Lahore 54792, Pakistan. Electronic address: rahman.saleem@lums.edu.pk. ^[8]

关键词 Anticancer Bis-amide Microtubule stabilizing agents Mouse organoid and human organoid models Tubulin polymerization