Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.

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作者： Tolga,Lokumcu ^[1] ; Murat,Iskar ^[2] ; Martin,Schneider ^[3] ; Dominic,Helm ^[3] ; Glynis,Klinke ^[4] ; Lisa,Schlicker ^[5] ; Frederic,Bethke ^[6] ; Gabriele,Müller ^[6] ; Karsten,Richter ^[7] ; Gernot,Poschet ^[4] ; Emma,Phillips ^[6] ; Violaine,Goidts ^[6]

作者单位： Brain Tumor Translational Targets, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.;Faculty of Biosciences, University of Heidelberg, Heidelberg 69120, Germany. ^[1] Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland. ^[2] Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. ^[3] Metabolomics Core Technology Platform, Centre for Organismal Studies, Heidelberg University, Heidelberg 69120, Germany. ^[4] Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.;Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. ^[5] Brain Tumor Translational Targets, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. ^[6] Core Facility Electron Microscopy, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany. ^[7]

关键词 exosomes fatty acids glioblastoma glioblastoma stem-like cells metabolomics proteomics small extracellular vesicles

主题词人类(Humans);胶质母细胞瘤(Glioblastoma);脂肪酸类(Fatty Acids);蛋白质组学(Proteomics);肿瘤干细胞(Neoplastic Stem Cells);脑肿瘤(Brain Neoplasms)

DOI 10.1021/acsnano.3c11427

PMID 38207106

发布时间 2024-10-23

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