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Platanosides from Platanus × acerifolia: New molecules, SAR, and target validation of a strong lead for drug-resistant bacterial infections and the associated sepsis.

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第一作者： Xi-Ying,Wu

第一单位： Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, PR China; School of Pharmacy, Fudan University, Shanghai 201203, PR China; Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, PR China.

作者： Xi-Ying,Wu ^[1] ; Ze-Yu,Zhao ^[2] ; Ezzat E A,Osman ^[3] ; Xiao-Juan,Wang ^[4] ; Yeun-Mun,Choo ^[5] ; Menny M,Benjamin ^[6] ; Juan,Xiong ^[7] ; Mark T,Hamann ^[8] ; Cheng,Luo ^[9] ; Jin-Feng,Hu ^[10]

作者单位： Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, PR China; School of Pharmacy, Fudan University, Shanghai 201203, PR China; Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, PR China. ^[1] Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, PR China; School of Pharmacy, Fudan University, Shanghai 201203, PR China. ^[2] Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornaish El-Nile St., Giza 12411, Egypt. ^[3] School of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu, PR China; Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston 29425-5700, USA. ^[4] Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia. Electronic address: ymchoo@um.edu.my. ^[5] Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston 29425-5700, USA. ^[6] School of Pharmacy, Fudan University, Shanghai 201203, PR China. ^[7] Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston 29425-5700, USA. Electronic address: hamannm@musc.edu. ^[8] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203, PR China. ^[9] Institute of Natural Medicine and Health Products, School of Pharmaceutical Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Zhejiang 318000, PR China; School of Pharmacy, Fudan University, Shanghai 201203, PR China; Colleges of Pharmacy and Medicine, Medical University of South Carolina, Charleston 29425-5700, USA. Electronic address: jfhu@fudan.edu.cn. ^[10]

关键词 Antibacterial Enterococcus faecium Molecular docking Molecular ion networking (MoIN)Platanosides Platanus × acerifolia Staphylococcus aureus Structure-activity relationship (SAR)Target validation