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Design, synthesis and biological evaluation of 6-chloro-quinolin-2-one derivatives as novel FXIa inhibitors.

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第一作者： Yanshi,Wang

第一单位： Tianjin Key Laboratory of Molecular Design and Drug Discovery, Puchuang Pharmaceutical Technology (Tianjin) Co., Ltd, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China.

作者： Yanshi,Wang ^[1] ; Jianglin,Yuan ^[1] ; Sida,Yan ^[1] ; Peng,Liu ^[1] ; Zhichao,Zheng ^[1] ; Shijun,Zhang ^[1] ; Fancui,Meng ^[1] ; Wei,Liu ^[1] ; Changjiang,Huang ^[2] ; Qunchao,Wei ^[3]

作者单位： Tianjin Key Laboratory of Molecular Design and Drug Discovery, Puchuang Pharmaceutical Technology (Tianjin) Co., Ltd, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China. ^[1] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Puchuang Pharmaceutical Technology (Tianjin) Co., Ltd, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China. Electronic address: huangcj@tipr.com.cn. ^[2] Tianjin Key Laboratory of Molecular Design and Drug Discovery, Puchuang Pharmaceutical Technology (Tianjin) Co., Ltd, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China; National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, 306 Huiren Road, Tianjin 300301, PR China. Electronic address: weiqc@tipr.com.cn. ^[3]

关键词 6-chloro-quinolin-2-one derivatives Clotting assay FXIa inhibitors Intravenous administration

医学主题词动物(Animals);大鼠(Rats);血液凝固(Blood Coagulation);部分促凝血酶原时间(Partial Thromboplastin Time);因子Ⅺa(Factor XIa)

DOI 10.1016/j.bmcl.2024.129610

PMID 38211702

发布时间 2025-07-15

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