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Unsupervised spatially embedded deep representation of spatial transcriptomics.

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第一作者： Hang,Xu

第一单位： Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.

作者： Hang,Xu ^[1] ; Huazhu,Fu ^[2] ; Yahui,Long ^[1] ; Kok Siong,Ang ^[1] ; Raman,Sethi ^[1] ; Kelvin,Chong ^[1] ; Mengwei,Li ^[1] ; Rom,Uddamvathanak ^[1] ; Hong Kai,Lee ^[1] ; Jingjing,Ling ^[1] ; Ao,Chen ^[3] ; Ling,Shao ^[4] ; Longqi,Liu ^[5] ; Jinmiao,Chen ^[6]

作者单位： Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore. ^[1] Institute of High-Performance Computing (IHPC), Agency for Science, Technology and Research (A*STAR), Singapore, 138632, Singapore. ^[2] BGI Research-Southwest, BGI, Chongqing, 401329, China.;JFL-BGI STOmics Center, Jinfeng Laboratory, Chongqing, 401329, China. ^[3] UCAS-Terminus AI Lab, University of Chinese Academy of Sciences, Beijing, China. ^[4] BGI-ShenZhen, Shenzhen, 518103, China. ^[5] Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore. chen_jinmiao@immunol.a-star.edu.sg.;Immunology Translational Research Program, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), 5 Science Drive 2, BlkMD4, Level 3, Singapore, 117545, Singapore. chen_jinmiao@immunol.a-star.edu.sg. ^[6]

关键词 Batch integration Gene imputation Spatial clustering Spatial transcriptomics Trajectory inference Variational graph auto-encoder

医学主题词人类(Humans);基因表达谱(Gene Expression Profiling);细胞间通讯(Cell Communication);聚类分析(Cluster Analysis)

DOI 10.1186/s13073-024-01283-x

PMID 38217035

发布时间 2024-07-06

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准确一般字义偏差语意偏离译文作用小提交