Synthesis, antioxidant and neuroprotective analysis of diversely functionalized α-aryl-N-alkyl nitrones as potential agents for ischemic stroke therapy.

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作者： Alejandro,Escobar-Peso ^[1] ; Emma,Martínez-Alonso ^[2] ; Dimitra,Hadjipavlou-Litina ^[3] ; Alberto,Alcázar ^[4] ; José,Marco-Contelles ^[5]

作者单位： Department of Research, Ramón y Cajal University Hospital, IRYCIS, 28034, Madrid, Spain; Laboratory of Medicinal Chemistry, Institute of General Organic Chemistry (CSIC), 28006, Madrid, Spain. Electronic address: alejandro.escobar@hrc.es. ^[1] Department of Research, Ramón y Cajal University Hospital, IRYCIS, 28034, Madrid, Spain. ^[2] Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. ^[3] Department of Research, Ramón y Cajal University Hospital, IRYCIS, 28034, Madrid, Spain. Electronic address: alberto.alcazar@hrc.es. ^[4] Laboratory of Medicinal Chemistry, Institute of General Organic Chemistry (CSIC), 28006, Madrid, Spain; Centre for Biomedical Network Research on Rare Diseases (CIBERER), CIBER, ISCIII, Madrid, Spain. Electronic address: jlmarco@iqog.csic.es. ^[5]

关键词 Antioxidants Drug development Ischemic stroke Nitrones Phenyl-derived nitrones Structure-activity relationship

主题词人类(Humans);抗氧化剂(Antioxidants);神经保护药(Neuroprotective Agents);氧化氮类(Nitrogen Oxides);缺血(Ischemia);环氮氧化物(Cyclic N-Oxides)

DOI 10.1016/j.ejmech.2024.116133

PMID 38218126

发布时间 2024-02-05

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