首页> European journal of medicinal chemistry> Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes.

Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes.

导出 LinkOut

翻译打印收藏纠错

第一作者： Perihan A,Elzahhar

第一单位： Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.

作者： Perihan A,Elzahhar ^[1] ; Rebecca,Orioli ^[2] ; Nayera W,Hassan ^[1] ; Silvia,Gobbi ^[2] ; Federica,Belluti ^[2] ; Hala F,Labib ^[3] ; Ahmed F,El-Yazbi ^[4] ; Rasha,Nassra ^[5] ; Ahmed S F,Belal ^[6] ; Alessandra,Bisi ^[7]

作者单位： Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. ^[1] Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy. ^[2] Department of Pharmaceutical Chemistry, College of Pharmacy, Arab Academy of Science Technology and Maritime Transport, Alexandria, Egypt. ^[3] Faculty of Pharmacy and the Research and Innovation Hub, Alamein International University, Alamein, 5060335, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. ^[4] Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Egypt. ^[5] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt. Electronic address: ahmed.belal@alexu.edu.eg. ^[6] Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy. Electronic address: alessandra.bisi@unibo.it. ^[7]

关键词 15-LOX COX Chromone Inflammation N-acylhydrazone mPGES-1