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A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures.

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第一作者： Amy G,Aslamkhan

第一单位： Nonclinical Drug Safety, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, United States.

作者： Amy G,Aslamkhan ^[1] ; Laura,Michna ^[1] ; Alexei,Podtelezhnikov ^[1] ; Katerina,Vlasakova ^[1] ; Hiroshi,Suemizu ^[2] ; Yasuyuki,Ohnishi ^[2] ; Liping,Liu ^[1] ; Pamela,Lane ^[1] ; Qiuwei,Xu ^[1] ; Matthew C,Kuhls ^[1] ; Zhibin,Wang ^[1] ; Stephen,Pacchione ^[1] ; Zoltan,Erdos ^[1] ; Rodger William,Tracy ^[3] ; Kenneth,Koeplinger ^[3] ; Nagaraja,Muniappa ^[1] ; John,Valentine ^[3] ; Alema,Galijatovic-Idrizbegovic ^[1] ; Warren E,Glaab ^[1] ; Frank D,Sistare ^[1] ; Jose,Lebron ^[1]

作者单位： Nonclinical Drug Safety, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, United States. ^[1] Laboratory Animal Research, Central Institute for Experimental Animals, 210-0821 Kawasaki-ku, Kawasaki 3-25-12 Tonomachi, Japan. ^[2] Pharmacokinetics, Dynamics, Metabolism and Bioanalytics, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA, United States. ^[3]

关键词 biomarker fialuridine humanized liver mouse liver mitochondrial DNA p53

DOI 10.1093/toxres/tfad120

PMID 38223529

发布时间 2025-01-12

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A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures.

Toxicology research

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Toxicology research

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A mechanistic biomarker investigation of fialuridine hepatotoxicity using the chimeric TK-NOG Hu-liver mouse model and in vitro micropatterned hepatocyte cocultures.

Toxicology research

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Toxicology research

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