首页> European journal of medicinal chemistry> HDAC/NAMPT dual inhibitors overcome initial drug-resistance in p53-null leukemia cells.

HDAC/NAMPT dual inhibitors overcome initial drug-resistance in p53-null leukemia cells.

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第一作者： Kairui,Yue

第一单位： Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China.

作者： Kairui,Yue ^[1] ; Simin,Sun ^[1] ; Enqiang,Liu ^[1] ; Jinyu,Liu ^[1] ; Baogeng,Hou ^[1] ; Kangjing,Qi ^[1] ; C James,Chou ^[2] ; Yuqi,Jiang ^[3] ; Xiaoyang,Li ^[4]

作者单位： Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China. ^[1] Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, 29425, United States; Neuroene Therapeutics, JLABS at the Children's National Research and Innovation Campus, 7144 13th PL NW, Washington, DC, 20012-2358, United States. Electronic address: cjameschou@outlook.com. ^[2] Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266003, China; Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao, Shandong, 266003, China. Electronic address: jiangyuqi@ouc.edu.cn. ^[3] Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266071, China; Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266003, China; Center for Targeted Protein Degradation and Drug Discovery, Ocean University of China, Qingdao, Shandong, 266003, China. Electronic address: lixiaoyang@ouc.edu.cn. ^[4]

关键词 Anti-cancer HDAC inhibitor Histone deacetylases Multi-target inhibitor Nicotinamide phosphoribosyltransferase

医学主题词人类(Humans);组蛋白脱乙酰基酶抑制剂(Histone Deacetylase Inhibitors);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);烟酰胺磷酸核糖基转移酶(Nicotinamide Phosphoribosyltransferase);细胞系, 肿瘤(Cell Line, Tumor);白血病(Leukemia)

DOI 10.1016/j.ejmech.2024.116127

PMID 38224650

发布时间 2024-02-06

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