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Dihydropyrimidine dehydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: FUSAFE individual patient data meta-analysis.

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第一作者: Gwénaël,Le Teuff
第一单位: Service de Biostatistique et d'Epidémiologie, Gustave Roussy, Oncostat U1018 INSERM, labeled Ligue Contre le Cancer, Université Paris-Saclay, Villejuif, France. Gwenael.LETEUFF@gustaveroussy.fr.
作者单位: Service de Biostatistique et d'Epidémiologie, Gustave Roussy, Oncostat U1018 INSERM, labeled Ligue Contre le Cancer, Université Paris-Saclay, Villejuif, France. Gwenael.LETEUFF@gustaveroussy.fr. [1] Service de Biostatistique et d'Epidémiologie, Gustave Roussy, Oncostat U1018 INSERM, labeled Ligue Contre le Cancer, Université Paris-Saclay, Villejuif, France. [2] Service de Biochimie et Biologie Moléculaire, CHU Carémeau, Nîmes, France. [3] Department of cancer medicine, Gustave-Roussy Cancer Campus, Paris-Saclay and Paris-Sud Universities, Villejuif, France.;Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC, 5096, Paris, France. [4] Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Cancer Center, Rochester, MN, USA. [5] Université Paris-Cité, SIRIC CARPEM, Department of Gastroenterology and Digestive Oncology, Georges Pompidou European Hospital, AP-HP, Paris, France. [6] Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. [7] Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK. [8] Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.;Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, University of Tuebingen, Tuebingen, Germany.;Cluster of Excellence IFIT (EXC 2180) "Image-Guided and Functionally Instructed Tumor Therapies", University of Tübingen, 72074, Tübingen, Germany. [9] Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, the Netherlands. [10] Department of Clinical Chemistry, Bern University Hospital, University of Bern, Inselspital, Bern, Switzerland. [11] Purine Research Laboratory, St Thomas' Hospital, London, UK. [12] Norwich Medical School, University of East Anglia, Norwich, UK. [13] Sahlgrenska University Hospital, Goteborg, Sweden. [14] Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. [15] LMU Munich, University Hospital, Campus Grosshadern, Munich, Germany. [16] National Institute of Oncology, Budapest, Hungary. [17] College of Heath, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia. [18] Amsterdam UMC, location University of Amsterdam, Laboratory Genetic Metabolic Diseases, Meibergdreef 9, Amsterdam, The Netherlands.;Cancer Center Amsterdam, Cancer Biology and Immunology, Imaging and biomarkers, Amsterdam, The Netherlands. [19] Intermountain Precision Genomics, Intermountain Healthcare, St George, UT, USA. [20] Oncopharmacology Laboratory, Centre Antoine Lacassagne, Nice, France. [21] Institut Claudius Regaud, IUCT-Oncopôle and CRCT, University of Toulouse, Inserm, Toulouse, France. [22] Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC, 5096, Paris, France.;Hôpital Européen Georges Pompidou, Hôpitaux Universitaires Paris Ouest, Paris, France. [23] Nuffield Division of Clinical and Laboratory Sciences and University of Oxford, Oxford, UK. [24] Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. [25]
DOI 10.1038/s41416-023-02517-2
PMID 38225422
发布时间 2025-08-21
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