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Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation.

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第一作者： Samantha A,Swenson

第一单位： Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.;Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.

作者： Samantha A,Swenson ^[1] ; Kasidy K,Dobish ^[2] ; Hendrik C,Peters ^[3] ; C,Bea Winship ^[3] ; R,Willow Hynes-Smith ^[4] ; Mika,Caplan ^[4] ; Karli J,Wittorf ^[4] ; Gargi,Ghosal ^[4] ; Shannon M,Buckley ^[5]

作者单位： Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA.;Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA. ^[1] Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.;Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA.;Huntsman Cancer Institute, University of Utah, Salt Lake City, UT,USA. ^[2] Huntsman Cancer Institute, University of Utah, Salt Lake City, UT,USA. ^[3] Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA.;Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA. ^[4] Huntsman Cancer Institute, University of Utah, Salt Lake City, UT,USA.;Department of Internal Medicine, Division of Hematology and Hematopoietic Malignancies, University of Utah, Salt Lake City, UT, USA. ^[5]

关键词 DPPA5 E3 ligase pluripotency ubiquitination

医学主题词细胞分化(Cell Differentiation);胚胎干细胞(Embryonic Stem Cells);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);泛素(Ubiquitin);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);泛素化(Ubiquitination);动物(Animals);小鼠(Mice);F框蛋白质类(F-Box Proteins)

DOI 10.1093/stmcls/sxae004

PMID 38227647

发布时间 2025-07-18

基金项目

P20 GM121316/GM/NIGMS NIH HHS/United States R01 CA263504/CA/NCI NIH HHS/United States R37 CA262635/CA/NCI NIH HHS/United States P30 CA042014/CA/NCI NIH HHS/United States P30 CA036727/CA/NCI NIH HHS/United States R01 GM141232/GM/NIGMS NIH HHS/United States

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