Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device.

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作者： Narciso,Pavon ^[1] ; Karmen,Diep ^[2] ; Feiyu,Yang ^[3] ; Rebecca,Sebastian ^[1] ; Beatriz,Martinez-Martin ^[4] ; Ravi,Ranjan ^[5] ; Yubing,Sun ^[6] ; ChangHui,Pak ^[7]

作者单位： Graduate Program in Neuroscience and Behavior, UMass Amherst, Amherst, MA 01003, USA; Department of Biochemistry and Molecular Biology, UMass Amherst, Amherst, MA 01003, USA. ^[1] Department of Biochemistry and Molecular Biology, UMass Amherst, Amherst, MA 01003, USA. ^[2] Department of Mechanical and Industrial Engineering, UMass Amherst, Amherst, MA 01003, USA. ^[3] Department of Biochemistry and Molecular Biology, UMass Amherst, Amherst, MA 01003, USA; Graduate Program in Molecular and Cellular Biology, UMass Amherst, Amherst, MA 01003, USA. ^[4] Genomics Core, Institute of Applied Life Sciences, UMass Amherst, Amherst, MA 01003, USA. ^[5] Department of Mechanical and Industrial Engineering, UMass Amherst, Amherst, MA 01003, USA. Electronic address: ybsun@umass.edu. ^[6] Department of Biochemistry and Molecular Biology, UMass Amherst, Amherst, MA 01003, USA. Electronic address: cpak@umass.edu. ^[7]

关键词 CP: Biotechnology CP: Stem cell GABAergic projection neurons brain organoids diffusion dorsal-ventral axis ganglionic eminence interneurons morphogen gradient patterning

主题词女(雌)性(Female);妊娠(Pregnancy);人类(Humans);脑(Brain);中间神经元(Interneurons);细胞分化(Cell Differentiation);类器官(Organoids)

DOI 10.1016/j.crmeth.2023.100689

PMID 38228151

发布时间 2024-02-10

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Cell reports methods

2024年4卷1期

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Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device.

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Patterning ganglionic eminences in developing human brain organoids using a morphogen-gradient-inducing device.

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