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The characteristics of pre-existing humoral imprint determine efficacy of S. aureus vaccines and support alternative vaccine approaches.

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第一作者： J R,Caldera

第一单位： Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

作者： J R,Caldera ^[1] ; Chih-Ming,Tsai ^[2] ; Desmond,Trieu ^[2] ; Cesia,Gonzalez ^[2] ; Irshad A,Hajam ^[2] ; Xin,Du ^[2] ; Brian,Lin ^[2] ; George Y,Liu ^[3]

作者单位： Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. ^[1] Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA. ^[2] Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Division of Infectious Diseases, Rady Children's Hospital, San Diego, CA 92123, USA. Electronic address: gyliu@ucsd.edu. ^[3]

关键词 S.?aureus antibody interference immune imprinting immunization original antigenic sin vaccine

医学主题词动物(Animals);人类(Humans);小鼠(Mice);免疫法(Immunization);耐甲氧西林金黄色葡萄球菌(Methicillin-Resistant Staphylococcus aureus);葡萄球菌菌苗(Staphylococcal Vaccines);金黄色葡萄球菌(Staphylococcus aureus);疫苗(Vaccines);临床试验(主题)(Clinical Trials as Topic)

DOI 10.1016/j.xcrm.2023.101360

PMID 38232694

发布时间 2024-10-23

基金项目

R01 AI127406/AI/NIAID NIH HHS/United States R01 AI144694/AI/NIAID NIH HHS/United States R01 AI179098/AI/NIAID NIH HHS/United States R01 AI181321/AI/NIAID NIH HHS/United States

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