换一批
换一批Targeting the Main Protease (M<sup>pro</sup>, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies.
作者：
Nadide,Altincekic [1]
;
Nathalie,Jores [2]
;
Frank,Löhr [1]
;
Christian,Richter [2]
;
Claus,Ehrhardt [2]
;
Marcel J J,Blommers [3]
;
Hannes,Berg [1]
;
Sare,Öztürk [2]
;
Santosh L,Gande [4]
;
Verena,Linhard [5]
;
Julien,Orts [1]
;
Marie Jose,Abi Saad [2]
;
Matthias,Bütikofer [1]
;
Janina,Kaderli [1]
;
B Göran,Karlsson [2]
;
Ulrika,Brath [1]
;
Mattias,Hedenström [2]
;
Gerhard,Gröbner [6]
;
Uwe H,Sauer [6]
;
Anastassis,Perrakis [7]
;
Julian,Langer [7]
;
Lucia,Banci [8]
;
Francesca,Cantini [9]
;
Marco,Fragai [8]
;
Deborah,Grifagni [10]
;
Tatjana,Barthel [10]
;
Jan,Wollenhaupt [11]
;
Manfred S,Weiss [12]
;
Angus,Robertson [13]
;
Adriaan,Bax [14]
;
Sridhar,Sreeramulu [15]
;
Harald,Schwalbe [14]
作者单位：
Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
[1]
Center of Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
[2]
Institute of Biophysical Chemistry, Goethe University Frankfurt am Main, D-60438 Frankfurt, Germany.
[3]
Department of Biochemistry, University of Zurich, 8093 Zurich, Switzerland.
[4]
SavernaTherapeutics, 4105 Biel-Benken, Switzerland.
[5]
Department of Pharmaceutical Sciences, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
[6]
Swiss Federal Institute of Technology, Laboratory of Physical Chemistry, ETH Zurich, 8093 Zürich, Switzerland.
[7]
Swedish NMR Centre, Department of Chemistry and Molecular Biology, University of Gothenburg, SE40530 Göteborg, Sweden.
[8]
SciLifeLab, University of Gothenburg, SE40530 Göteborg, Sweden.
[9]
Swedish NMR Centre, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden.
[10]
Protein Production Sweden, Department of Chemistry, University of Umeå, SE-90187 Umeå, Sweden.
[11]
Oncode Institute and Division of Biochemistry, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands.
[12]
Max Planck Institute of Biophysics, D-60438 Frankfurt am Main, Germany.
[13]
Magnetic Resonance Center and Department of Chemistry, University of Florence, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
[14]
Consorzio Interuniversitario Risonanze Magnetiche Metalloproteine, Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy.
[15]
Macromolecular Crystallography, Helmholtz-Zentrum Berlin, Albert-Einstein-Str. 15, D-12489 Berlin, Germany.
[16]
NIH, LCP NIDDK, Bethesda, Maryland 20892, United States.
[17]
主题词
药物发现(Drug Discovery);催化域(Catalytic Domain);磁共振波谱学(Magnetic Resonance Spectroscopy);肽水解酶类(Peptide Hydrolases);蛋白酶抑制药(Protease Inhibitors);抗病毒药(Antiviral Agents)
DOI
10.1021/acschembio.3c00720
PMID
38232960
发布时间
2024-06-13
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ACS chemical biology
ACS chemical biology
563-574页
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