首页> Nature communications> Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy.

Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy.

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第一作者： Binh An,Nguyen

第一单位： Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.;Department of Biophysics, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.;Peter O'Donnell Jr Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.

作者： Binh An,Nguyen ^[1] ; Virender,Singh ^[1] ; Shumaila,Afrin ^[1] ; Anna,Yakubovska ^[1] ; Lanie,Wang ^[1] ; Yasmin,Ahmed ^[1] ; Rose,Pedretti ^[1] ; Maria Del Carmen,Fernandez-Ramirez ^[1] ; Preeti,Singh ^[1] ; Maja,Pękała ^[1] ; Luis O,Cabrera Hernandez ^[1] ; Siddharth,Kumar ^[1] ; Andrew,Lemoff ^[2] ; Roman,Gonzalez-Prieto ^[3] ; Michael R,Sawaya ^[4] ; David S,Eisenberg ^[4] ; Merrill Douglas,Benson ^[5] ; Lorena,Saelices ^[6]

作者单位： Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.;Department of Biophysics, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.;Peter O'Donnell Jr Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. ^[1] Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[2] Andalusian Center for Molecular Biology and regenerative Medicine (CABIMER), Universidad de Sevilla-CSIC-Universidad-Pablo de Olavide, Departmento de Biología Celular, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain. ^[3] Department of Biological Chemistry, University of California, Los Angeles, Howard Hughes Medical Institute, Los Angeles, CA, USA. ^[4] Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. ^[5] Center for Alzheimer's and Neurodegenerative Diseases, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. lorena.saelicesgomez@utsouthwestern.edu.;Department of Biophysics, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. lorena.saelicesgomez@utsouthwestern.edu.;Peter O'Donnell Jr Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. lorena.saelicesgomez@utsouthwestern.edu. ^[6]

医学主题词人类(Humans);淀粉样蛋白(Amyloid);淀粉样神经病, 家族性(Amyloid Neuropathies, Familial);冷冻电子显微镜检查(Cryoelectron Microscopy);前白蛋白(Prealbumin);心脏(Heart);脑疾病(Brain Diseases)

DOI 10.1038/s41467-024-44820-3

PMID 38233397

发布时间 2026-05-11

基金项目

S10 OD020103/OD/NIH HHS/United States S10 OD021685/OD/NIH HHS/United States DP2 HL163810/HL/NHLBI NIH HHS/United States U24 GM129539/GM/NIGMS NIH HHS/United States U24 GM129547/GM/NIGMS NIH HHS/United States

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