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Disruption of gut barrier integrity and host-microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus.

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第一作者： R,Forlano

第一单位： Liver unit/Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.

作者： R,Forlano ^[1] ; L,Martinez-Gili ^[2] ; P,Takis ^[3] ; J,Miguens-Blanco ^[1] ; T,Liu ^[1] ; E,Triantafyllou ^[1] ; C,Skinner ^[1] ; R,Loomba ^[4] ; M,Thursz ^[1] ; J R,Marchesi ^[1] ; B H,Mullish ^[1] ; P,Manousou ^[1]

作者单位： Liver unit/Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK. ^[1] Liver unit/Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK.;Section of Bioinformatics, Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK. ^[2] National Phenome Centre, Imperial College London, London, UK. ^[3] NAFLD Research Center, Division of Gastroenterology. University of California at San Diego, La Jolla, CA, USA. ^[4]

关键词 MASLD Microbiome fibrosis gut permeability metabolomics type-2 diabetes mellitus

医学主题词人类(Humans);RNA, 核糖体, 16S(RNA, Ribosomal, 16S);代谢疾病(Metabolic Diseases);脂肪肝(Fatty Liver);糖尿病, 2型(Diabetes Mellitus, Type 2);纤维化(Fibrosis)

DOI 10.1080/19490976.2024.2304157

PMID 38235661

发布时间 2024-08-08

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