Super enhancer loci of EGFR regulate EGFR variant 8 through enhancer RNA and strongly associate with survival in HNSCCs.

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作者： Sundaram Reddy,Chakkarappan ^[1] ; Karuppiah Vijayamuthuramalingam,Umadharshini ^[2] ; Shankar,Dhamodharan ^[2] ; Mathew Maria,Rose ^[2] ; Govindasamy,Gopu ^[3] ; Avaniyapuram Kannan,Murugan ^[4] ; Ituro,Inoue ^[5] ; Arasambattu Kannan,Munirajan ^[6]

作者单位： Department of Health Research, Multi Disciplinary Research Unit (DHR-MRU), Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India. ^[1] Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India. ^[2] Department of Surgical Oncology, Rajiv Gandhi Government General Hospital, Madras Medical College, Chennai, 600003, India. ^[3] Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, 11211, Riyadh, Saudi Arabia. ^[4] Human Genetics Laboratory, National Institute of Genetics, Mishima, 411-8540, Japan. ^[5] Department of Health Research, Multi Disciplinary Research Unit (DHR-MRU), Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India. akmunirajan@gmail.com. ^[6] Department of Genetics, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India. akmunirajan@gmail.com. ^[7]

关键词 Chromatin CpG EGFR EGFR-AS1 H3K27ac eRNA

主题词人类(Humans);染色质(Chromatin);头颈部肿瘤(Head and Neck Neoplasms)

DOI 10.1007/s00438-023-02089-z

PMID 38236481

发布时间 2024-01-19

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