Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma.

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作者： Shohei,Abe ^[1] ; Atsuhiro,Masuda ^[2] ; Tomonori,Matsumoto ^[3] ; Jun,Inoue ^[1] ; Hirochika,Toyama ^[4] ; Arata,Sakai ^[1] ; Takashi,Kobayashi ^[1] ; Takeshi,Tanaka ^[1] ; Masahiro,Tsujimae ^[1] ; Kohei,Yamakawa ^[1] ; Masanori,Gonda ^[1] ; Shigeto,Masuda ^[1] ; Hisahiro,Uemura ^[1] ; Shinya,Kohashi ^[1] ; Noriko,Inomata ^[1] ; Kae,Nagao ^[1] ; Yoshiyuki,Harada ^[1] ; Mika,Miki ^[1] ; Yosuke,Irie ^[1] ; Noriko,Juri ^[1] ; Testuhisa,Ko ^[1] ; Yusuke,Yokotani ^[1] ; Yuki,Oka ^[1] ; Shogo,Ota ^[1] ; Maki,Kanzawa ^[5] ; Tomoo,Itoh ^[5] ; Toshio,Imai ^[1] ; Takumi,Fukumoto ^[4] ; Eiji,Hara ^[6] ; Yuzo,Kodama ^[1]

作者单位： Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan. ^[1] Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan. atmasuda@med.kobe-u.ac.jp. ^[2] Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, 565-0871, Japan. tomomatsumoto@biken.osaka-u.ac.jp. ^[3] Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan. ^[4] Division of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Hyogo, 650-0017, Japan. ^[5] Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, 565-0871, Japan. ^[6]

关键词 Major driver gene alteration Pancreatic ductal adenocarcinoma Prognosis Tumor microbiome Tumor-infiltrating lymphocytes

主题词人类(Humans);RNA, 核糖体, 16S(RNA, Ribosomal, 16S);胰腺肿瘤(Pancreatic Neoplasms);癌, 胰腺管(Carcinoma, Pancreatic Ductal);预后(Prognosis)

DOI 10.1007/s00535-023-02069-5

PMID 38242997

发布时间 2024-05-29

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