(+)-Lipoic acid reduces mitochondrial unfolded protein response and attenuates oxidative stress and aging in an in vitro model of non-alcoholic fatty liver disease.

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作者： Lucia,Longhitano ^[1] ; Alfio,Distefano ^[1] ; Nicolò,Musso ^[1] ; Paolo,Bonacci ^[1] ; Laura,Orlando ^[1] ; Sebastiano,Giallongo ^[1] ; Daniele,Tibullo ^[1] ; Simona,Denaro ^[1] ; Giuseppe,Lazzarino ^[1] ; Jessica,Ferrigno ^[1] ; Anna,Nicolosi ^[2] ; Amer M,Alanazi ^[3] ; Federico,Salomone ^[4] ; Emanuela,Tropea ^[1] ; Ignazio Alberto,Barbagallo ^[1] ; Vincenzo,Bramanti ^[5] ; Giovanni,Li Volti ^[6] ; Giacomo,Lazzarino ^[7] ; Daniele,Torella ^[8] ; Angela Maria,Amorini ^[1]

作者单位： Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy. ^[1] Hospital Pharmacy Unit, Ospedale Cannizzaro, 95125, Catania, Italy. ^[2] Pharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia. ^[3] Division of Gastroenterology, Ospedale Di Acireale, Azienda Sanitaria Provinciale Di Catania, Catania, Italy. ^[4] U.O.S. Laboratory Analysis, Maggiore "Nino Baglieri" Hospital - ASP Ragusa, 97015, Modica (RG), Italy. ^[5] Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy. livolti@unict.it. ^[6] UniCamillus-Saint Camillus International University of Health Sciences, Via Di Sant'Alessandro 8, 00131, Rome, Italy. ^[7] Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy. ^[8]

关键词 Mitochondrial dysfunction Non-alcoholic fatty liver disease Oxidative stress Unfolded protein re-sponse