Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD.

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作者： Bilal,Khalil ^[1] ; Miriam,Linsenmeier ^[2] ; Courtney L,Smith ^[3] ; James,Shorter ^[4] ; Wilfried,Rossoll ^[5]

作者单位： Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, U.S.A. ^[1] Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, U.S.A. ^[2] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, U.S.A.;Mayo Clinic Graduate School of Biomedical Sciences, Neuroscience Track, Mayo Clinic, Jacksonville, FL, 32224, U.S.A. ^[3] Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, U.S.A.. jshorter@pennmedicine.upenn.edu. ^[4] Department of Neuroscience, Mayo Clinic, Jacksonville, FL, 32224, U.S.A.. rossoll.wilfried@mayo.edu. ^[5]

关键词 Aberrant phase transition Amyotrophic lateral sclerosis Chaperone FUS Frontotemporal dementia Importin Nuclear pore Nucleocytoplasmic transport Protein aggregation RNA-binding proteins TDP-43

主题词人类(Humans);额颞叶痴呆(Frontotemporal Dementia);肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);主动转运, 细胞核(Active Transport, Cell Nucleus);DNA结合蛋白质类(DNA-Binding Proteins);朊病毒(Prions)

DOI 10.1186/s13024-023-00698-1

PMID 38254150

发布时间 2024-12-18

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准确一般字义偏差语意偏离译文作用小提交