Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells.

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作者： Yong Hwan,Kim ^[1] ; Na Yeon,Park ^[1] ; Doo Sin,Jo ^[2] ; Ji-Eun,Bae ^[3] ; Joon Bum,Kim ^[1] ; Kyuhee,Park ^[4] ; Kwiwan,Jeong ^[4] ; Pansoo,Kim ^[2] ; Eunbyul,Yeom ^[5] ; Dong-Hyung,Cho ^[6]

作者单位： School of Life Sciences, BK21 FOUR KNU Creative Bio Research Group, Kyungpook National University, Daegu 41566, Republic of Korea. ^[1] ORGASIS Corp., Suwon 16229, Republic of Korea. ^[2] KNU LAMP Research Center, KNU Institute of Basic Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea. ^[3] Bio Industry Department, Gyeonggido Business & Science Accelerator, Suwon 16229, Republic of Korea. ^[4] School of Life Sciences, BK21 FOUR KNU Creative Bio Research Group, Kyungpook National University, Daegu 41566, Republic of Korea.;KNU LAMP Research Center, KNU Institute of Basic Sciences, College of Natural Sciences, Kyungpook National University, Daegu 41566, Republic of Korea. ^[5] School of Life Sciences, BK21 FOUR KNU Creative Bio Research Group, Kyungpook National University, Daegu 41566, Republic of Korea.;ORGASIS Corp., Suwon 16229, Republic of Korea.;Organelle Institute, Kyungpook National University, Daegu 41566, Republic of Korea. ^[6]

关键词 HIF-α VH298 VHL E3 ligase autophagy pexophagy

主题词人类(Humans);自噬(Autophagy);内环境稳定(Homeostasis);脑视网膜血管瘤抑制蛋白质(Von Hippel-Lindau Tumor Suppressor Protein);环丙烷类(Cyclopropanes);吡咯烷类(Pyrrolidines);噻唑类(Thiazoles)

DOI 10.3390/molecules29020482

PMID 38257395

发布时间 2024-10-23

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