Dual Inhibition of CDK4/6 and XPO1 Induces Senescence With Acquired Vulnerability to CRBN-Based PROTAC Drugs.

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作者： Hui,Wang ^[1] ; Shengxian,Yuan ^[2] ; Quan,Zheng ^[3] ; Sisi,Zhang ^[1] ; Qianqian,Zhang ^[4] ; Shuyi,Ji ^[5] ; Wei,Wang ^[1] ; Ying,Cao ^[1] ; Yuchen,Guo ^[1] ; Xupeng,Yang ^[5] ; Haigang,Geng ^[6] ; Fan,Yang ^[7] ; Shuijun,Xi ^[5] ; Guangzhi,Jin ^[8] ; Jianming,Zhang ^[9] ; Qiang,Gao ^[5] ; René,Bernards ^[10] ; Wenxin,Qin ^[11] ; Cun,Wang ^[12]

作者单位： State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[1] The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China. ^[2] Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[3] National Research Center for Translational Medicine (Shanghai), State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[4] Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China. ^[5] Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[6] Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[7] Department of Interventional Radiology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. ^[8] Institute of Translational Medicine, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, China. ^[9] State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands. Electronic address: r.bernards@nki.nl. ^[10] State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: wxqin@sjtu.edu.cn. ^[11] State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: cwang@shsci.org. ^[12]

关键词 CDK4/6 Inhibitor Senescence Senolytics XPO1 Inhibitor