Uncovering the colorectal cancer immunotherapeutic potential: Evening primrose (Oenothera biennis) root extract and its active compound oenothein B targeting the PD-1/PD-L1 blockade.

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作者： Eun-Ji,Lee ^[1] ; Young Soo,Kim ^[1] ; Ji Hye,Kim ^[1] ; Kyeong Wan,Woo ^[2] ; Young-Hoon,Park ^[3] ; Jung-Hye,Ha ^[3] ; Wei,Li ^[1] ; Tae In,Kim ^[1] ; Byeong Kwan,An ^[4] ; Hyun Woo,Cho ^[2] ; Jung Ho,Han ^[1] ; Jang-Gi,Choi ^[5] ; Hwan-Suck,Chung ^[6]

作者单位： Korean Medicine Application Center, Korea Institute of Oriental Medicine (KIOM), 70, Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea. ^[1] National Development Institute of Korea Medicine, 27, Wondogwandeok-gil, Jangheung-eup, Jangheung-gun, Jeollanam-do 59319, Republic of Korea. ^[2] New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 80, Cheombok-ro, Dong-gu, Daegu 41061, Republic of Korea. ^[3] National Development Institute of Korea Medicine, 94, Hwarang-ro, Gyeongsan-si, Gyeongsangbuk-do 38540, Republic of Korea. ^[4] Korean Medicine Application Center, Korea Institute of Oriental Medicine (KIOM), 70, Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea. Electronic address: jang-gichoi@kiom.re.kr. ^[5] Korean Medicine Application Center, Korea Institute of Oriental Medicine (KIOM), 70, Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea; Korean Convergence Medical Science Major, KIOM Campus, University of Science and Technology (UST), 70, Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea. Electronic address: hschung@kiom.re.kr. ^[6]

关键词 Humanized PD-1 mouse Immune checkpoint Oenothein B Oenothera biennis Programmed cell death ligand 1 Programmed cell death protein 1