Antisolvent fabrication of monodisperse liposomes using novel ultrasonic microreactors: Process optimization, performance comparison and intensification effect.

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作者： Caihe,Peng ^[1] ; Xiaojing,Zhu ^[2] ; Jie,Zhang ^[3] ; Wenzhong,Zhao ^[4] ; Jingfu,Jia ^[3] ; Zhilin,Wu ^[5] ; Zhixin,Yu ^[6] ; Zhengya,Dong ^[7]

作者单位： School of Pharmacy, Changchun University of Chinese Medicine, 130117 Changchun, China. ^[1] Chemistry and Chemical Engineering Guangdong Laboratory, 515031 Shantou, China. Electronic address: zhuxj@ccelab.com.cn. ^[2] Chemistry and Chemical Engineering Guangdong Laboratory, 515031 Shantou, China. ^[3] La Fang Jahwa Co., Ltd., 515144 Shantou, China. ^[4] Chemistry and Chemical Engineering Guangdong Laboratory, 515031 Shantou, China; College of Chemistry and Chemical Engineering, Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 515063 Shantou, China. ^[5] School of Pharmacy, Changchun University of Chinese Medicine, 130117 Changchun, China. Electronic address: yuzx01@ccucm.edu.cn. ^[6] Chemistry and Chemical Engineering Guangdong Laboratory, 515031 Shantou, China; College of Chemistry and Chemical Engineering, Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 515063 Shantou, China; MoGe um-Flow Technology Co., Ltd., 515031 Shantou, China. Electronic address: zydong@ccelab.com.cn. ^[7]

关键词 Co-flow High throughput Impinge flow Monodisperse liposomes Ultrasonic microreactor

主题词脂质体(Liposomes);超声学(Ultrasonics);药物载体(Drug Carriers);微流体学(Microfluidics);脂类(Lipids);粒子大小(Particle Size)

DOI 10.1016/j.ultsonch.2024.106769

PMID 38266590

发布时间 2024-10-23

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