Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins.

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作者： Michael R,Strickland ^[1] ; Michael J,Rau ^[2] ; Brock,Summers ^[2] ; Katherine,Basore ^[2] ; John,Wulf ^[2] ; Hong,Jiang ^[1] ; Yun,Chen ^[3] ; Jason D,Ulrich ^[4] ; Gwendalyn J,Randolph ^[5] ; Rui,Zhang ^[6] ; James A J,Fitzpatrick ^[2] ; Anil G,Cashikar ^[7] ; David M,Holtzman ^[8]

作者单位： Department of Neurology, 660 S. Euclid Ave., St. Louis, MO 63110, USA. ^[1] Washington University Center for Cellular Imaging, 660 S. Euclid Ave., St. Louis, MO 63110, USA. ^[2] Department of Neurology, 660 S. Euclid Ave., St. Louis, MO 63110, USA; Department of Pathology and Immunology, 660 S. Euclid Ave., St. Louis, MO 63110, USA. ^[3] Department of Neurology, 660 S. Euclid Ave., St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, 660 S. Euclid Ave., St. Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, 4488 Forest Park Ave., St. Louis, MO 63108, USA. ^[4] Department of Pathology and Immunology, 660 S. Euclid Ave., St. Louis, MO 63110, USA. ^[5] Department of Biochemistry and Molecular Biophysics, 660 S. Euclid Ave., St. Louis, MO 63110, USA. ^[6] Hope Center for Neurological Disorders, 660 S. Euclid Ave., St. Louis, MO 63110, USA; Department of Psychiatry, 660 S. Euclid Ave., St. Louis, MO 63110, USA; Taylor Family institute for Innovative Psychiatric Research, 660 S. Euclid Ave., St. Louis, MO 63110, USA. ^[7] Department of Neurology, 660 S. Euclid Ave., St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, 660 S. Euclid Ave., St. Louis, MO 63110, USA; Knight Alzheimer's Disease Research Center, 4488 Forest Park Ave., St. Louis, MO 63108, USA. Electronic address: holtzman@wustl.edu. ^[8]

关键词 Alzheimer’s disease ApoE HDL apolipoprotein E astrocytes cryo-EM glia lipoprotein

主题词星形细胞(Astrocytes);载脂蛋白E类(Apolipoproteins E);脂蛋白类, HDL(Lipoproteins, HDL);中枢神经系统(Central Nervous System);载脂蛋白E4(Apolipoprotein E4);载脂蛋白E3(Apolipoprotein E3);脂蛋白类(Lipoproteins)

DOI 10.1016/j.neuron.2023.12.018

PMID 38266643

发布时间 2024-04-16

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