Temporal genome-wide fitness analysis of <i>Mycobacterium marinum</i> during infection reveals the genetic requirement for virulence and survival in amoebae and microglial cells.

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作者： Louise H,Lefrançois ^[1] ; Jahn,Nitschke ^[1] ; Huihai,Wu ^[2] ; Gaël,Panis ^[3] ; Julien,Prados ^[3] ; Rachel E,Butler ^[4] ; Tom A,Mendum ^[2] ; Nabil,Hanna ^[2] ; Graham R,Stewart ^[1] ; Thierry,Soldati ^[2]

作者单位： Department of Biochemistry, Faculty of Science, University of Geneva, Science II, Geneva, Switzerland. ^[1] Department of Microbial Sciences, School of Biosciences, University of Surrey, Guildford, Surrey, United Kingdom. ^[2] Department of Microbiology and Molecular Medicine, Faculty of Medicine/CMU, University of Geneva, Institute of Genetics and Genomics in Geneva (iGE3), Genève, Switzerland. ^[3] Bioinformatics Support Platform for data analysis, Geneva University, Medicine Faculty, Geneva, Switzerland. ^[4]

关键词 BV2 microglial cells Dictyostelium discoideum Mycobacterium marinum Tn-Seq essentiality phenotypic profiling

主题词动物(Animals);小鼠(Mice);人类(Humans);毒力(Virulence);小神经胶质细胞(Microglia);海分枝杆菌(Mycobacterium marinum);变形虫属(Amoeba);网柱菌属(Dictyostelium);结核(Tuberculosis);结核分枝杆菌(Mycobacterium tuberculosis);脂类(Lipids)

DOI 10.1128/msystems.01326-23

PMID 38270456

发布时间 2024-02-22

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Temporal genome-wide fitness analysis of <i>Mycobacterium marinum</i> during infection reveals the genetic requirement for virulence and survival in amoebae and microglial cells.

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Temporal genome-wide fitness analysis of <i>Mycobacterium marinum</i> during infection reveals the genetic requirement for virulence and survival in amoebae and microglial cells.

mSystems

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mSystems

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