Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma.

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第一作者： Feng,Zhang

第一单位： Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.;Shanghai Institute of Liver Disease, Shanghai, China.;Shanghai Medical College of Fudan University, Shanghai, China.

作者： Feng,Zhang ^[1] ; Wenfeng,Liu ^[1] ; Fansheng,Meng ^[2] ; Qiuyu,Jiang ^[1] ; Wenqing,Tang ^[1] ; Zhiyong,Liu ^[1] ; Xiahui,Lin ^[1] ; Ruyi,Xue ^[1] ; Si,Zhang ^[3] ; Ling,Dong ^[4]

作者单位： Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China.;Shanghai Institute of Liver Disease, Shanghai, China.;Shanghai Medical College of Fudan University, Shanghai, China. ^[1] Shanghai Medical College of Fudan University, Shanghai, China. ^[2] Shanghai Medical College of Fudan University, Shanghai, China dong.ling@zs-hospital.sh.cn zhangsi@fudan.edu.cn. ^[3] Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China dong.ling@zs-hospital.sh.cn zhangsi@fudan.edu.cn.;Shanghai Institute of Liver Disease, Shanghai, China.;Shanghai Medical College of Fudan University, Shanghai, China. ^[4]

关键词 Immune Checkpoint Inhibitors Macrophages Tumor Microenvironment

主题词小鼠(Mice);动物(Animals);人类(Humans);癌, 肝细胞(Carcinoma, Hepatocellular);肝肿瘤(Liver Neoplasms);巨噬细胞(Macrophages);免疫疗法(Immunotherapy);预后(Prognosis);肿瘤微环境(Tumor Microenvironment);1-烷基-2-乙酰甘油磷酸胆碱酯酶(1-Alkyl-2-acetylglycerophosphocholine Esterase)

DOI 10.1136/jitc-2023-008094

PMID 38272562

发布时间 2024-10-23

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Journal for immunotherapy of cancer

2024年12卷1期

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Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma.

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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Inhibiting PLA2G7 reverses the immunosuppressive function of intratumoral macrophages and augments immunotherapy response in hepatocellular carcinoma.

Journal for immunotherapy of cancer

相似文献

Journal for immunotherapy of cancer

相关期刊

检索历史清除