Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert anti-apoptotic and anti-inflammatory effects <i>in vitro</i> and modulate mRNA expression in a cisplatin-induced kidney injury murine model.

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作者： Erika,Rendra ^[1] ; Adriana Torres,Crigna ^[1] ; Cristina,Daniele ^[2] ; Carsten,Sticht ^[2] ; Maike,Cueppers ^[1] ; Mark Andreas,Kluth ^[3] ; Christoph,Ganss ^[3] ; Markus H,Frank ^[4] ; Norbert,Gretz ^[2] ; Karen,Bieback ^[5]

作者单位： Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service Baden-Württemberg - Hessen, Mannheim, Germany. ^[1] Medical Faculty Mannheim, Medical Research Centre, Heidelberg University, Mannheim, Germany. ^[2] RHEACELL GmbH & Co. KG, Heidelberg, Germany. ^[3] Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.;Harvard Stem Cell Institute, Harvard University, Cambridge, MA, United States.;Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Boston, MA, United States.;School of Medical and Health Sciences, Edith Cowan University, Perth, WA, Australia. ^[4] Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Service Baden-Württemberg - Hessen, Mannheim, Germany.;Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. ^[5]

关键词 ABCB5 PBMC cisplatin immune response kidney injury mRNA expression profile macrophage mesenchymal stromal cells