首页> Journal of translational medicine> Single-nucleus transcriptomic analysis reveals the relationship between gene expression in oligodendrocyte lineage and major depressive disorder.

Single-nucleus transcriptomic analysis reveals the relationship between gene expression in oligodendrocyte lineage and major depressive disorder.

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第一作者： Yinping,Xie

第一单位： Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan, China.

作者： Yinping,Xie ^[1] ; Lijuan,Chen ^[2] ; Leimin,Wang ^[3] ; Tongou,Liu ^[4] ; Yage,Zheng ^[5] ; Lujia,Si ^[6] ; Hailong,Ge ^[6] ; Hong,Xu ^[6] ; Ling,Xiao ^[7] ; Gaohua,Wang ^[8]

作者单位： Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan, China. ^[1] Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China. ^[2] School of Automation, China University of Geosciences, Wuhan, China. ^[3] The First Clinical College of Hubei University of Chinese Medicine, Wuhan, China. ^[4] Judicial Appraisal Institute, Renmin Hospital of Hubei Province, Wuhan, China. ^[5] Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China. ^[6] Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan, China. 327550377@qq.com. ^[7] Institute of Neuropsychiatry, Renmin Hospital of Wuhan University, Wuhan, China. wgh6402@whu.edu.cn. ^[8]

关键词 Guided regularized random forest algorithm MALAT1 Major depressive disorder Oligodendrocyte lineage development Single-cell transcriptome

医学主题词人类(Humans);抑郁症, 更年期(Depressive Disorder, Major);细胞谱系(Cell Lineage);原位杂交, 荧光(In Situ Hybridization, Fluorescence);额叶前皮质(Prefrontal Cortex);基因表达谱(Gene Expression Profiling);基因表达(Gene Expression)

DOI 10.1186/s12967-023-04727-x

PMID 38281050

发布时间 2024-10-23

基金项目

2042022kf1101/Fundamental Research Funds for the Central Universities 82071523/National Natural Science Foundation of China 62076229/National Natural Science Foundation of China

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