Exogenous butyrate inhibits butyrogenic metabolism and alters virulence phenotypes in <i>Clostridioides difficile</i>.

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作者： Daniel A,Pensinger ^[1] ; Horia A,Dobrila ^[2] ; David M,Stevenson ^[1] ; Nicole D,Hryckowian ^[2] ; Daniel,Amador-Noguez ^[3] ; Andrew J,Hryckowian ^[4]

作者单位： Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. ^[1] Department of Medical Microbiology & Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. ^[2] Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA. ^[3] Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin, USA. ^[4]

关键词 enteric pathogens gram-positive bacteria metabolism pathogenesis

主题词人类(Humans);动物(Animals);小鼠(Mice);梭菌感染(Clostridium Infections);丁酸盐类(Butyrates);毒力(Virulence);腹泻(Diarrhea)

DOI 10.1128/mbio.02535-23

PMID 38289141

发布时间 2024-03-15

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