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首页> Bioorganic chemistry> Novel 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide based thiosemicarbazides as potent and selective inhibitors of tumor-associated human carbonic anhydrase IX and XII: Synthesis, cytotoxicity, and molecular modelling studies.

Novel 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide based thiosemicarbazides as potent and selective inhibitors of tumor-associated human carbonic anhydrase IX and XII: Synthesis, cytotoxicity, and molecular modelling studies.

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作者： Kübra,Demir-Yazıcı ^[1] ; Muhammed,Trawally ^[1] ; Silvia,Bua ^[2] ; Dilek,Öztürk-Civelek ^[3] ; Atilla,Akdemir ^[4] ; Claudiu T,Supuran ^[2] ; Özlen,Güzel-Akdemir ^[5]

作者单位： Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey; Department of Pharmaceutical Chemistry, Institute of Graduate Studies in Health Sciences, Istanbul University, 34126 Istanbul, Turkey. ^[1] Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, 50019, Sesto Fiorentino, Florence, Italy. ^[2] Department of Pharmacology, Faculty of Pharmacy, Bezmialem Vakif University, 34093 Istanbul, Turkey. ^[3] Department of Pharmacology, Faculty of Pharmacy, Istinye University, 34408 Istanbul, Turkey. ^[4] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey. Electronic address: oguzel@istanbul.edu.tr. ^[5]

关键词 2-(Hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide Carbonic anhydrase Cytotoxicity Ensemble docking Molecular dynamics simulations Tumor-associated hCA IX/XII

主题词人类(Humans);构效关系(Structure-Activity Relationship);碳酸酐酶抑制剂(Carbonic Anhydrase Inhibitors);肿瘤(Neoplasms);磺胺类(Sulfonamides);抗原, 肿瘤(Antigens, Neoplasm);碳酸酐酶Ⅰ(Carbonic Anhydrase I);蛋白质亚型(Protein Isoforms);吲哚类(Indoles);分子结构(Molecular Structure);氨基脲类(Semicarbazides)

DOI 10.1016/j.bioorg.2024.107096

PMID 38290186

发布时间 2024-02-19

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Bioorganic chemistry

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