H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient.

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作者： Tamara,Boschert ^[1] ; Kristina,Kromer ^[2] ; Taga,Lerner ^[3] ; Katharina,Lindner ^[2] ; Gordon,Haltenhof ^[4] ; Chin Leng,Tan ^[4] ; Kristine,Jähne ^[1] ; Isabel,Poschke ^[2] ; Lukas,Bunse ^[5] ; Philipp,Eisele ^[1] ; Niklas,Grassl ^[1] ; Iris,Mildenberger ^[2] ; Katharina,Sahm ^[1] ; Michael,Platten ^[1] ; John M,Lindner ^[5] ; Edward W,Green ^[1]

作者单位： CCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[1] Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. ^[2] Helmholtz Institute for Translational Oncology (HI-TRON Mainz) - A Helmholtz Institute of the DKFZ, Mainz, Germany. ^[3] BioMed X GmbH, Heidelberg, Germany. ^[4] Immune Monitoring Unit, DKFZ and National Center for Tumour Diseases (NCT), Heidelberg, Germany. ^[5] Department of Neurology, Medical Faculty Mannheim, MCTN Heidelberg University, Mannheim, Germany. ^[6] DKFZ Hector Cancer Institute at the University Medical Center Mannheim, Mannheim Germany. ^[7]

主题词人类(Humans);T淋巴细胞(T-Lymphocytes);HLA-DR抗原(HLA-DR Antigens);接种(Vaccination);神经胶质瘤(Glioma);表位(Epitopes)

DOI 10.1126/sciadv.adi9091

PMID 38306431

发布时间 2024-02-05

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Science advances

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H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient.

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H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient.

Science advances

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