Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.

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作者： Mudiwa N,Muwanigwa ^[1] ; Jennifer,Modamio-Chamarro ^[1] ; Paul M A,Antony ^[2] ; Gemma,Gomez-Giro ^[1] ; Rejko,Krüger ^[3] ; Silvia,Bolognin ^[1] ; Jens C,Schwamborn ^[4]

作者单位： Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Belvaux, Luxembourg. ^[1] Bioimaging Platform, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Belvaux, Luxembourg. ^[2] Translational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Belvaux, Luxembourg. ^[3] Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4367 Belvaux, Luxembourg. Electronic address: jens.schwamborn@uni.lu. ^[4]

关键词 Astrosenescence Midbrain organoids α-Synuclein

主题词人类(Humans);帕金森病(Parkinson Disease);α突触核蛋白(alpha-Synuclein);星形细胞(Astrocytes);神经变性疾病(Neurodegenerative Diseases);中脑(Mesencephalon);类器官(Organoids);黑质(Substantia Nigra)

DOI 10.1016/j.mcn.2024.103919

PMID 38307302

发布时间 2024-03-11

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Molecular and cellular neurosciences

2024年128卷

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Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.

Molecular and cellular neurosciences

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Molecular and cellular neurosciences

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Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease.

Molecular and cellular neurosciences

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Molecular and cellular neurosciences

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