Discrimination of pancreato-biliary cancer and pancreatitis patients by non-invasive liquid biopsy.

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作者： Christina,Hartwig ^[1] ; Jan,Müller ^[2] ; Hagen,Klett ^[1] ; Dina,Kouhestani ^[3] ; Anke,Mittelstädt ^[4] ; Anna,Anthuber ^[5] ; Paul,David ^[6] ; Maximilian,Brunner ^[6] ; Anne,Jacobsen ^[6] ; Karolina,Glanz ^[6] ; Izabela,Swierzy ^[6] ; Lotta,Roßdeutsch ^[6] ; Bettina,Klösch ^[1] ; Robert,Grützmann ^[6] ; Timo,Wittenberger ^[6] ; Kai,Sohn ^[6] ; Georg F,Weber ^[6]

作者单位： Innovation Field In-vitro Diagnostics, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany. ^[1] Institute for Interfacial Engineering and Plasma Technology IGVP, University of Stuttgart, Stuttgart, Germany. ^[2] Center for Integrative Bioinformatics Vienna (CIBIV), Max Perutz Labs, University of Vienna and Medical University of Vienna, Vienna BioCenter, Vienna, Austria. ^[3] Vienna BioCenter PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna, Austria. ^[4] Genedata GmbH, Munich, Germany. ^[5] Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. ^[6] Deutsches Zentrum für Immuntherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. ^[7] Comprehensive Cancer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. ^[8] Bavarian Cancer Research Center (BZKF), Erlangen, Germany. ^[9] Innovation Field In-vitro Diagnostics, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany. Kai.Sohn@igb.fraunhofer.de. ^[10] Department of Surgery, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. Georg.Weber@uk-erlangen.de. ^[11] Deutsches Zentrum für Immuntherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. Georg.Weber@uk-erlangen.de. ^[12] Comprehensive Cancer Center, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany. Georg.Weber@uk-erlangen.de. ^[13] Bavarian Cancer Research Center (BZKF), Erlangen, Germany. Georg.Weber@uk-erlangen.de. ^[14]

关键词 DMRs Hybridization and capture IPMN Methylation Next-generation sequencing Non-invasive diagnostics Pancreatitis Pancreato-biliary cancer cfDNA cfMBD-Seq

主题词人类(Humans);胰腺肿瘤(Pancreatic Neoplasms);胰腺炎(Pancreatitis);癌, 胰腺管(Carcinoma, Pancreatic Ductal)

DOI 10.1186/s12943-024-01943-x

PMID 38308296

发布时间 2024-02-28

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