Crosstalk between endothelial cells with a non-canonical EndoMT phenotype and cardiomyocytes/fibroblasts via IGFBP5 aggravates TAC-induced cardiac dysfunction.

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第一作者： Yue,Li

第一单位： Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen, 518000, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China; Key Laboratory of Chronic Heart Failure, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China.

作者： Yue,Li ^[1] ; Shi-Hao,Ni ^[2] ; Xin,Liu ^[3] ; Shu-Ning,Sun ^[2] ; Gui-Chen,Ling ^[4] ; Jian-Ping,Deng ^[2] ; Xiao-Lu,Ou-Yang ^[2] ; Yu-Sheng,Huang ^[2] ; Huan,Li ^[2] ; Zi-Xin,Chen ^[2] ; Xiu-Fang,Huang ^[2] ; Shao-Xiang,Xian ^[2] ; Zhong-Qi,Yang ^[2] ; Ling-Jun,Wang ^[5] ; Hong-Yan,Wu ^[6] ; Lu,Lu ^[7]

作者单位： Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen, 518000, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China; Key Laboratory of Chronic Heart Failure, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China. ^[1] Guangzhou University of Chinese Medicine, Guangzhou, 510407, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China; Key Laboratory of Chronic Heart Failure, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China. ^[2] State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China; School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China. ^[3] The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, 518033, China. ^[4] Guangzhou University of Chinese Medicine, Guangzhou, 510407, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China; Key Laboratory of Chronic Heart Failure, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China. Electronic address: smu868@gzucm.edu.cn. ^[5] Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; Shenzhen Luohu Hospital of Traditional Chinese Medicine, Shenzhen, 518000, China. Electronic address: wu.hy@163.com. ^[6] Guangzhou University of Chinese Medicine, Guangzhou, 510407, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China; Key Laboratory of Chronic Heart Failure, Guangzhou University of Chinese Medicine, Guangzhou, 510407, China. Electronic address: coinland@gzucm.edu.cn. ^[7]

关键词 Cell crosstalk Endothelial cells with a transient fibrotic-like phenotype IGFBP5 Single-cell RNA sequencing TAC-induced pressure overload